Clinical Significance. In SLE, RNP antibodies have been associated with a relatively benign disease course with lower incidence of renal and central nervous system involvement. Patients may be considered positive for RNP antibodies when the RNP antibody result is significantly higher than the Sm antibody result.What are RNP antibodies?
Clinical Information. Antibodies to RNP occur in approximately 50% of patients with lupus erythematosus (LE) and in patients with other connective tissue diseases, notably mixed connective tissue disease (MCTD). MCTD is characterized by high levels of RNP antibodies without detectable Sm or double-stranded DNA (dsDNA) antibodies.What is normal range for RNP antibodies?
specific ANA-related antibodies to test high was RNP (>8 when the normal range is 0.0-0.9).What does high RNP antibodies mean?
High RNP titers are also often found in RA, Sjogren’s Syndrome, MS and other diseases but are not considered characteristic for these diseases. Anti-RNP are considered autoimmune antibodies and come about when cells die and their nuclear components are released into the surrounding environment where they can trigger an antibody response.