Keyword Analysis & Research: humoral response and cellular response


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What cells are involved in the humoral response?

The humoral response (or antibody‐mediated response) involves B cells that recognize antigens or pathogens that are circulating in the lymph or blood (“humor” is a medieval term for body fluid). The response follows this chain of events: Antigens bind to B cells.

What are the roles of B cells in a humoral response?

B cells have three functions: as antigen-presenting cells (see above), to secrete chemical messaging molecules called cytokines (the colored dots), and to produced antibodies as part of the humoral immune response. When still in the bone marrow, B cells develop membrane receptors – B-cell receptors or BCRs.

What are the steps in a humoral response?

It involves a humoral immune response that occurs in two stages: primary and secondary. The primary phase is set into motion upon the body’s first contact with an antigen (surface protein found on pathogen membranes); the secondary phase describes the immune-system reaction to subsequent contact with the same antigen.

What is the difference between humoral immunity and cell-mediated immunity?

Humoral immunity uses B cells to secrete antibodies that move around in the blood as a soluble protein. Cell-mediated immunity occurs through the activation of antigen-specific T cells.


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