Entamoeba histolytica Antigen, EIA - Entamoeba histolytica are intestinal parasites that infect a half billion people worldwide annually. Of those infected, most are infected with the non-pathogenic E. dispar, which has not been associated with disease.What is antibody and antigen detection?
Antibody detection is most useful in patients with extraintestinal disease (i.e., amebic liver abscess) when organisms are not generally found on stool examination. Antigen detection may be useful as an adjunct to microscopic diagnosis in detecting parasites and can distinguish between pathogenic and nonpathogenic infections.What is the EIA test for amebiasis?
The EIA test detects antibody specific for E. histolytica in approximately 95% of patients with extraintestinal amebiasis, 70% of patients with active intestinal infection, and 10% of asymptomatic persons who are passing cysts of E. histolytica.Can amebic liver abscess be diagnosed by circulating antigen?
DISCUSSION The major conclusion of this study is that amebic liver abscess can be diagnosed by the detection of circulating antigen. The TechLab E. histolyticaII kit was able to detect serum antigen (Gal/GalNAc lectin) in almost all patients with amebic liver abscess who had not received treatment with metronidazole.