TCR-engineered T cell therapy in solid tumors: State of the art …
https://www.science.org/doi/10.1126/sciadv.adf3700
WEBFeb 15, 2023 · TCR-T and CAR-T cell therapies consist in genetically engineered T cells, modified to express a receptor directed against a tumor antigen. CAR-T cell therapies were a considerable breakthrough in hematological cancers, with six therapies now FDA-approved, targeting CD19 or B cell maturation antigen ( 5, 6 ).
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