| Keyword | CPC | PCC | Volume | Score | Length of keyword |
|---|---|---|---|---|---|
| t cell receptor | 0.67 | 0.7 | 8297 | 91 | 15 |
| t | 1.9 | 0.5 | 2708 | 8 | 1 |
| cell | 1.75 | 1 | 3940 | 34 | 4 |
| receptor | 1.46 | 0.2 | 554 | 44 | 8 |
| Keyword | CPC | PCC | Volume | Score |
|---|---|---|---|---|
| t cell receptor | 1.62 | 0.8 | 3341 | 32 |
https://en.wikipedia.org/wiki/T-cell_receptor
WEBThe T-cell receptor (TCR) is a protein complex found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules.
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https://www.nature.com/articles/s41392-021-00823-w
WEBDec 13, 2021 · T cell receptor (TCR) signaling in health and disease. Kinjal Shah, Amr Al-Haidari, Jianmin Sun & Julhash U. Kazi. Signal Transduction and Targeted Therapy 6, Article number: 412 ( 2021 )...
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https://pubmed.ncbi.nlm.nih.gov/29261409/
WEBApr 26, 2018 · Receptors, Antigen, T-Cell. T cell receptors (TCRs) are protein complexes formed by six different polypeptides. In most T cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains that recognize peptide antigens associated with major histocompatibility complex molecules expressed on the surface of ….
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https://www.nature.com/articles/s41423-020-0367-1
WEBFeb 11, 2020 · The T cell receptor (TCR) is one of the most complicated receptors in mammalian cells, and its triggering mechanism remains mysterious. As an octamer complex, TCR comprises an antigen-binding...
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https://www.nature.com/articles/s12276-020-0435-8
WEBMay 21, 2020 · T cell activation requires extracellular stimulatory signals that are mainly mediated by T cell receptor (TCR) complexes. The TCR recognizes antigens on major histocompatibility complex molecules...
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845206/
WEBThe T-cell receptor (TCR)-CD3 complex serves as a central paradigm for general principles of receptor assembly, ligand recognition, and signaling in the immune system. There is no other receptor system that matches the …
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801066/
WEBIntroduction. The specificity of a T cell for antigen is defined by its T cell antigen receptor (TCR) which acts as an antigen detector. Because the TCR is generated through the rearrangement of genomic DNA segments during development, each T cell is endowed with a TCR of unique specificity – providing a clonal identity.
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https://bio.libretexts.org/Bookshelves/Microbiology/Microbiology_(Boundless)/11%3A_Immunology/11.08%3A_T_Cells_and_Cellular_Immunity/11.8E%3A_T_Cell_Receptors
WEBDec 24, 2022 · MHC molecules and peptides form complexes on the surface of antigen presenting cells (APCs). The receptor that recognizes these peptide-MHC complexes is called the T Cell Receptor (TCR). Clones of T cells …
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666445/
WEBDec 13, 2021 · T cells are key mediators in mounting an effective adaptive cell-mediated immune response. 1, 2 T cells continuously screen lymphoid and peripheral tissues for antigens such as peptides or lipids displayed by major histocompatibility complex (pMHC) molecules of other cells.
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https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/t-cell-receptor
WEBAbstract. The speed of T cell receptor (TCR) discovery has been revolutionized by barcode-based TCR sequencing approaches that allow the reconstitution of a T cell's paired alpha and beta TCR chain, and the process of TCR discovery promises to become ever faster and cheaper with the continuing development single cell analysis techniques.
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https://www.britannica.com/science/immune-system/T-cell-antigen-receptors
WEBA typical T cell may have as many as 20,000 receptor molecules on its membrane surface, all of either the alpha-beta or gamma-delta type. The T-cell receptor molecule is embedded in the membrane of the cell, and a portion of the molecule extends away from the cell surface into the area surrounding the cell.
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https://www.nature.com/articles/s41592-020-01020-3
WEBJan 6, 2021 · T cells are defined by their TCR sequences, which help T cells achieve highly specific TCR-dependent antigen recognition 1, 2, 3, 4. The antigen recognition triggers downstream...
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https://www.sciencedirect.com/topics/immunology-and-microbiology/t-cell-receptor
WEBT-Cell Receptors. Susan Pross, in xPharm: The Comprehensive Pharmacology Reference, 2007. Types of TCRs. The TCR of a given T-cell may actually be one of two types, either αβ (alpha/beta) or gd ( gamma/delta ), depending on the specific characteristics of …
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983839/
WEBJan 1, 2020 · This cardinal receptor of the mammalian immune system is expressed on T cells and is essential for protective responses to microbes and cancers. Because of its biomedical relevance, the TCR is one of the most extensively-studied receptors in …
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https://pubmed.ncbi.nlm.nih.gov/8034554/
WEBAbstract. T cells play a central role in the immune system as effectors and regulators. They become activated upon antigen recognition by their T-cell receptors (TCR). The TCR repertoire is established by developmentally regulated TCR gene rearrangements and shaped by predominantly intrathymic selection processes.
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https://www.thermofisher.com/us/en/home/life-science/cell-analysis/signaling-pathways/t-cell-receptor-tcr/t-cell-receptor-tcr-overview.html
WEBThe TCR (T-cell receptor) is a complex of integral membrane proteins that participate in the activation of T-cells in response to an antigen. Stimulation of TCR is triggered by MHC (major histocompatibility complex) molecules on cells with the antigen. Engagement of the TCR initiates positive and negative cascades that ultimately result in ...
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https://www.cell.com/cell-reports/fulltext/S2211-1247(23)01291-3
WEBOct 25, 2023 · Summary. Antigen-specific CD8 + T cells mediate pathogen clearance. T cell phenotype is influenced by T cell receptor (TCR) sequences and environmental signals. Quantitative comparisons of these factors in human disease, while challenging to obtain, can provide foundational insights into basic T cell biology.
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https://www.science.org/doi/10.1126/sciadv.adf3700
WEBFeb 15, 2023 · T cells expressing an engineered T cell receptor (TCR-T cells) represent a promising therapeutic alternative. The target repertoire is not limited to membrane proteins, and intrinsic features of TCRs such as high antigen sensitivity and near-to-physiological signaling may improve tumor cell detection and killing while improving T cell persistence.
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https://www.nature.com/articles/s41577-018-0020-8
WEBMay 22, 2018 · The remarkable T cell receptor (TCR) performs essential functions in the initiation of intracellular signals required for T cell development, repertoire selection and...
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https://my.clevelandclinic.org/health/body/24630-t-cells
WEBOverview. What are T-cells (T lymphocytes)? T-cells are a type of white blood cell called lymphocytes. They’re also called T lymphocytes. Lymphocytes play an essential role in your immune system. Your immune system fights infection-causing pathogens (viruses, bacteria, fungi and parasites) and harmful cells, like cancer cells.
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https://jamanetwork.com/journals/jamaoncology/fullarticle/2817658
WEB6 days ago · However, concerns regarding second primary malignant neoplasms (SPMNs) after CAR-T therapy remain and are potentially associated with cumulative exposure to chemotherapeutic agents, prolonged immunosuppression, or insertional mutagenesis. 1 The US Food and Drug Administration (FDA) issued a report about T-cell malignant …
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https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologics/fda-requires-boxed-warning-t-cell-malignancies-following-treatment-bcma-directed-or-cd19-directed
WEB6 days ago · In November 2023, the Food and Drug Administration (FDA) posted a safety communication to provide information about reports of T cell malignancies including chimeric antigen receptor CAR-positive ...
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https://www.nature.com/subjects/t-cell-receptor
WEBApr 13, 2024 · T-cell receptors (TCRs) recognize small protein fragments (peptides) that are displayed on the surface of antigen-presenting cells. Each T cell expresses a unique TCR that...
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https://www.mdpi.com/2073-4409/13/9/725
WEB1 day ago · Chimeric antigen receptor (CAR)-T cell therapy has proven to be a powerful treatment for hematological malignancies. The situation is very different in the case of solid tumors, for which no CAR-T-based therapy has yet been approved. There are many factors contributing to the absence of response in solid tumors to CAR-T cells, such as the …
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https://www.nature.com/articles/s41587-024-02210-6
WEB1 day ago · T cell receptor (TCR) gene therapy is a potent form of cellular immunotherapy in which patient T cells are genetically engineered to express TCRs with defined tumor reactivity. However, the ...
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https://www.nature.com/articles/s41573-023-00809-z
WEBOct 27, 2023 · The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects, amplifies and coordinates cellular immune responses to epitopes derived from cell surface and...
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