Keyword Analysis & Research: replication competent


Keyword Analysis

Keyword CPC PCC Volume Score Length of keyword
replication competent1.780.976622121
replication0.160.86289911
competent0.161909909

Keyword Research: People who searched replication competent also searched

Keyword CPC PCC Volume Score
replication competent1.130.3797859

Search Results related to replication competent on Search Engine

  • Meeting FDA Guidance recommendations for replication-competent …

    sciencedirect.com

    https://www.sciencedirect.com/science/article/pii/S2329050122001681

    WEBMar 9, 2023 · Biologic assays for replication-competent retrovirus detection. The diagram represents an analysis of vector supernatant, which typically contains replication-defective vector particles in excess of 10 9 particles per milliliter. The challenge is to detect an RCR present at very low numbers within the test material.

    DA: 74 PA: 13 MOZ Rank: 84

  • Meeting FDA Guidance recommendations for replication-competent …

    nih.gov

    https://pubmed.ncbi.nlm.nih.gov/36588821/

    WEBDec 2, 2022 · Meeting FDA Guidance recommendations for replication-competent virus and insertional oncogenesis testing. Mol Ther Methods Clin Dev. 2022 Dec 2:28:28-39. doi: 10.1016/j.omtm.2022.11.009. eCollection 2023 Mar 9.

    DA: 100 PA: 33 MOZ Rank: 34

  • The use of viral vectors in vaccine development | npj Vaccines

    nature.com

    https://www.nature.com/articles/s41541-022-00503-y

    WEBJul 4, 2022 · Adenovirus-based vectors can be either replication-competent or replication-defective, depending on whether or not they contain the entire early 1 (E1) region or part of it 10.

    DA: 60 PA: 69 MOZ Rank: 96

  • Principles of Retroviral Vector Design - Retroviruses - NCBI Bookshelf

    nih.gov

    https://www.ncbi.nlm.nih.gov/books/NBK19423/

    WEBPrinciples of Retroviral Vector Design. It is possible to make replication-competent retroviral vectors by adding sequences to existing viruses, but a more common design involves the replacement of retroviral sequences to create replication-defective vectors. In addition, the amount of foreign DNA that can be accommodated in replication ...

    DA: 82 PA: 22 MOZ Rank: 34

  • Replication-Competent Viral Vectors for Vaccine Delivery

    sciencedirect.com

    https://www.sciencedirect.com/science/article/pii/B9780128023020000017

    WEBJan 1, 2017 · Replication-competent Ad4 and Ad7 vectors delivered in enteric capsules have been used to vaccinate military personnel against respiratory and gastrointestinal illness since the 1970s, 110., 111. and now Ad4 is in development as a replicating vector as well.

    DA: 10 PA: 36 MOZ Rank: 22


  • Meeting FDA Guidance recommendations for replication-competent …

    cell.com

    https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(22)00168-1

    WEBMeeting FDA Guidance recommendations for replication-competent virus and insertional oncogenesis testing. Integrating vectors are associated with alterations in cellular function related to disruption of normal gene function. This has been associated with clonal expansion of cells and, in some instances, cancer.

    DA: 32 PA: 25 MOZ Rank: 79

  • Organ-specific genome diversity of replication-competent SARS …

    nature.com

    https://www.nature.com/articles/s41467-021-26884-7

    WEBNov 16, 2021 · In immunocompromised patients replication-competent SARS-CoV-2 spreads systemically and disseminates to extrapulmonary organs

    DA: 59 PA: 14 MOZ Rank: 36

  • Replication competent retrovirus testing (RCR) in the National …

    cell.com

    https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(22)00710-9

    WEBReplication competent retrovirus testing (RCR) in the National Gene Vector Biorepository: No evidence of RCR in 1,595 post-treatment peripheral blood samples obtained from 60 clinical trials. The clinical impact of any therapy requires the product be safe and effective. Gammaretroviral vectors pose several unique risks, including inadvertent ...

    DA: 26 PA: 50 MOZ Rank: 70

  • Replication-Competent Viruses as Cancer Immunotherapeutics: …

    nih.gov

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968310/

    WEBAug 1, 2015 · Replication-competent (oncolytic) viruses (OV) are not similarly limited to certain indications, as they can, via oncolysis, release the unique tumor epitopes from each patient's own tumor and can, therefore, be considered as in situ vaccines. Development of OVs has earlier been focusing on enhancing replication, lytic cell death, and systemic ...

    DA: 28 PA: 38 MOZ Rank: 54

  • Detection of Replication Competent Lentivirus Using a qPCR …

    nih.gov

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633339/

    WEBMar 3, 2018 · Although lentiviral vectors are ideal for delivery and stable integration of genes of interest into the host cell genome, they potentially pose risks to human health, such as integration-mediated transformation and generation of a replication competent lentivirus (RCL) capable of infecting non-target cells.

    DA: 2 PA: 34 MOZ Rank: 94