Guidelines for the Treatment of Hypothyroidism: Prepared ...
In contrast to D1 and D2, D3 is an inactivating deiodinase, catalyzing the conversion of T 3 to T 2 (3′,5′-T 2), and T 4 to reverse T 3 (rT 3: 3,3′,5′-T 3). Thus, the role of D3 is to clear T 3. Like D2, D3 is thought to have tissue-specific effects, preventing circulating T 3 from entering the nucleus.
DA: 4 PA: 96 MOZ Rank: 36